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Moreover, as a potential endogenous stimulus, miRNA exhibits an enhanced therapeutic activity superior to other stimuli such as pH, ATP, metal ion, enzyme and light because of its synergistic gene regulation therapy 22,23

The effect is selective muscle preservation rather than anabolic growth, perfectly aligned with the goal of pure fat reduction

The study hypothesized that pro-inflammatory gut environment further promotes changes in microbiota (Yadav et al., 2023)

Subsequently, a dual-aldehyde terminated PEG 2k -2CHO was utilized to crosslink the DC NP to obtain the surface charge reversal PEGylated DC NPs (PDC NP, 68.3% drug loading)

Measurement of metabolites Metabolites were quantified by ultra-performance liquid chromatographytandem mass spectrometry (LCMS-8060, Shimadzu) based on the Primary Metabolites package ver.2 (Shimadzu) 56,57